50-80 for adults and children ≥6 years of age
83-133 for children <6 years of age
On average, one IU of ALPROLIX per kg body weight increases the
circulating level of factor IX by approximately 1% (IU/dL) in adults and children ≥6
years of age and by 0.6% (IU/dL) in children <6 years of age. Consider
determining the patient’s in vivo recovery (in IU/dL per IU/kg) prior to elective
major surgery and verify that the target factor IX level has been achieved prior to
major surgery and for major bleeds.